Article
Chimerism in organ transplantation: conflicting experiments and clinical observations
1 May 2003
Abstract excerpt
The concept of chimerism has influenced our thinking about tolerance and rejection of organs and tissues since the beginning of modern transplantation. In macrochimerism, persisting donor-specific cells are easily detectable by flow cytometry at levels of several to 100%, usually after transient lymphoablation and bone marrow (or other cell) transplantation. Microchimerism refers to a state in which donor cells...