Article
Importance of allele frequency estimates in epidemiological studies.
Mutation research - 1 Sept 2004
Taioli Emanuela, Pedotti Paola, Garte Seymour
Abstract excerpt
This study addresses the issue of appropriate allelic frequency estimates in epidemiological studies. Reasons for imprecise estimate of allele frequency may be population stratification, and lack of power of many published studies to define true allele frequencies in the general population. As an example of the lack of power of epidemiological studies, we plot the frequency of GSTM1 deletion versus sample size...
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