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Article

Translational medicine and reliability of single-nucleotide polymorphism studies: can we believe in SNP reports or not?

International journal of medical sciences - 1 Jan 2011

Valachis Antonis, Mauri Davide, Neophytou Christodoulos, Polyzos Nikolaos P, Tsali Lampriani, Garras Antonios, Papanikolau Evangelos G

Abstract excerpt

BACKGROUND: The number of genetic association studies is increasing exponentially. Nonetheless, genetic association reports are prone to potential biases which may influence the reported outcome. AIM: We hypothesized that positive outcome for a determined polymorphism might be over-reported across genetic association studies analysing a small number of polymorphisms, when compared to studies analysing the same...

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PMID: 21897762
DOI: 10.7150/ijms.8.492
PMCID: PMC3167098

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GSTM1

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