Molecular Epidemiology of GSTM1 and GSTT1 Null Genotypes in High-Altitude Andean Populations of Peru.

Abstract excerpt

Glutathione-S-Transferase T1 (GSTT1) and M1 (GSTM1) are key enzymes involved in phase II detoxification. Null genotypes resulting from gene deletions are known to cause a complete loss of enzymatic activity and have been associated with altered xenobiotic metabolism in previous studies. Although genotype frequencies vary across ethnic groups, data from non-European populations, particularly Andean populations,...

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