Article
Penetrances of breast and ovarian cancer in a large series of families tested for BRCA1/2 mutations.
European journal of human genetics : EJHG - 1 Nov 2004
Marroni Fabio, Aretini Paolo, D'Andrea Emma, Caligo Maria Adelaide, Cortesi Laura, Viel Alessandra, Ricevuto Enrico, Montagna Marco, Cipollini Giovanna, Federico Massimo, Santarosa Manuela, Marchetti Paolo, Bailey-Wilson Joan E, Bevilacqua Generoso, Parmigiani Giovanni, Presciuttini Silvano
Abstract excerpt
Accurate estimates of breast and ovarian cancer penetrance in BRCA1/2 mutation carriers are crucial in genetic counseling. Estimation is difficult because of the low frequency of mutated alleles and the often-uncertain mechanisms of family ascertainment. We estimated the penetrances of breast and ovarian cancers in carriers of BRCA1/2 mutations by maximizing the retrospective likelihood of the genetic model,...
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