Article
Determining joint carrier probabilities of cancer-causing genes using Markov chain Monte Carlo methods.
Genetic epidemiology - 1 Sept 2005
Biswas Swati, Berry Donald A
Abstract excerpt
In genetic counseling for cancer risk, the probability of carrying a mutation of a cancer-causing gene plays an important role. Family history of various cancers is important in calculating this probability. BRCAPRO is a widely used software for calculating the probability of carrying mutations in BRCA1 and BRCA2 genes given the family history of breast and ovarian cancer in first- and second-degree relatives....
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