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BRCA1 and BRCA2 genetic test in high risk patients and families: counselling and management.

Oncology reports - 1 Dec 2010

Marchina Eleonora, Fontana Maria Grazia, Speziani Michela, Salvi Alessandro, Ricca Giuseppe, Di Lorenzo Diego, Gervasi Maria, Caimi Luigi, Barlati Sergio

Abstract excerpt

Hereditary breast cancer accounts for 5-10% of all cases of breast cancer and 10-15% of ovarian cancer and is characterised by dominant inheritance, early onset, the severity of the disease and bilaterality. About 30% of cases with hereditary breast and ovarian cancer have mutations in the BRCA1 and BRCA2 genes. Women with a mutation in the BRCA1 gene have a 80-90% lifetime risk of developing breast cancer, and...

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Identifiers

PMID: 21042765
DOI: 10.3892/or_00001031

Genes

BRCA1
BRCA2

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