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Estimate of the penetrance of BRCA mutation and the COS software for the assessment of BRCA mutation probability.

Familial cancer - 1 Mar 2015

Berrino Jacopo, Berrino Franco, Francisci Silvia, Peissel Bernard, Azzollini Jacopo, Pensotti Valeria, Radice Paolo, Pasanisi Patrizia, Manoukian Siranoush

Abstract excerpt

We have designed the user-friendly COS software with the intent to improve estimation of the probability of a family carrying a deleterious BRCA gene mutation. The COS software is similar to the widely-used Bayesian-based BRCAPRO software, but it incorporates improved assumptions on cancer incidence in women with and without a deleterious mutation, takes into account relatives up to the fourth degree and allows...

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Identifiers

PMID: 25373702
DOI: 10.1007/s10689-014-9766-8

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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