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Article

Activation state of the Ras2 protein and glucose-induced signaling in Saccharomyces cerevisiae.

The Journal of biological chemistry - 5 Nov 2004

Colombo Sonia, Ronchetti Daniela, Thevelein Johan M, Winderickx Joris, Martegani Enzo

Abstract excerpt

The activity of adenylate cyclase in the yeast Saccharomyces cerevisiae is controlled by two G-protein systems, the Ras proteins and the Galpha protein Gpa2. Glucose activation of cAMP synthesis is thought to be mediated by Gpa2 and its G-protein-coupled receptor Gpr1. Using a sensitive GTP-loading assay for Ras2 we demonstrate that glucose addition also triggers a fast increase in the GTP loading state of Ras2...

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Identifiers

PMID: 15339905
DOI: 10.1074/jbc.M405136200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation state of the Ras2 protein and glucose-induced signaling in Saccharomyces cerevisiae.PMID 15339905Read ↗

A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose.Semantic proximity Read ↗

Ras and Gpa2 mediate one branch of a redundant glucose signaling pathway in yeast.Semantic proximity Read ↗

Cdc25 is not the signal receiver for glucose induced cAMP response in S. cerevisiae.Semantic proximity Read ↗

The C-terminal part of the CDC25 gene product plays a key role in signal transduction in the glucose-induced modulation of cAMP level in Saccharomyces cerevisiae.Semantic proximity Read ↗

Direct activation of fission yeast adenylate cyclase by the Gpa2 Galpha of the glucose signaling pathway.Semantic proximity Read ↗

Multi-omics analysis of glucose-mediated signaling by a moonlighting Gβ protein Asc1/RACK1Semantic proximity Read ↗

Glucose repression of fbp1 transcription of Schizosaccharomyces pombe is partially regulated by adenylate cyclase activation by a G protein alpha subunit encoded by gpa2 (git8).Semantic proximity Read ↗

Involvement of the CDC25 gene product in the signal transmission pathway of the glucose-induced RAS-mediated cAMP signal in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Yeast alpha-mating factor receptor and G-protein-linked adenylyl cyclase inhibition requires RAS2 and GPA2 activities.Semantic proximity Read ↗

Ras membrane targeting is essential for glucose signaling but not for viability in yeast.Semantic proximity Read ↗

Multi-omics analysis of glucose-mediated signaling by a moonlighting Gβ protein Asc1/RACK1.Semantic proximity Read ↗

Schizosaccharomyces pombe adenylate cyclase suppressor mutations suggest a role for cAMP phosphodiesterase regulation in feedback control of glucose/cAMP signaling.Semantic proximity Read ↗

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