Article
A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose.
Molecular microbiology - 1 Jun 1999
Kraakman L, Lemaire K, Ma P, Teunissen A W, Donaton M C, Van Dijck P, Winderickx J, de Winde J H, Thevelein J M
Abstract excerpt
In the yeast Saccharomyces cerevisiae the accumulation of cAMP is controlled by an elaborate pathway. Only two triggers of the Ras adenylate cyclase pathway are known. Intracellular acidification induces a Ras-mediated long-lasting cAMP increase. Addition of glucose to cells grown on a non-fermentable carbon source or to stationary-phase cells triggers a transient burst in the intracellular cAMP level. This...
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