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Article

Involvement of the CDC25 gene product in the signal transmission pathway of the glucose-induced RAS-mediated cAMP signal in the yeast Saccharomyces cerevisiae.

Journal of general microbiology - 1 Feb 1991

van Aelst L, Jans A W, Thevelein J M

Abstract excerpt

Addition of glucose or related fermentable sugars to derepressed cells of the yeast Saccharomyces cerevisiae triggers a RAS-protein-mediated cAMP signal, which induces a protein phosphorylation cascade. Yeast strains without a functional CDC25 gene were deficient in basal cAMP synthesis and in th...

Topics

Adenosine Triphosphate
Adenylyl Cyclases
Cell Cycle Proteins
Cyclic AMP
Fungal Proteins
Glucose
Hydrogen-Ion Concentration
Mutation
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Signal Transduction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Temperature

ras Proteins

ras-GRF1

Source

Identifiers

PMID: 1849965
DOI: 10.1099/00221287-137-2-341

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1849965-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Involvement of the CDC25 gene product in the signal transmission pathway of the glucose-induced RAS-mediated cAMP signal in the yeast Saccharomyces cerevisiae.PMID 1849965Read ↗

The C-terminal part of the CDC25 gene product plays a key role in signal transduction in the glucose-induced modulation of cAMP level in Saccharomyces cerevisiae.Semantic proximity Read ↗

Inactivation of the CDC25 gene product in Saccharomyces cerevisiae leads to a decrease in glycolytic activity which is independent of cAMP levels.Semantic proximity Read ↗

Glucose-induced activation of plasma membrane H(+)-ATPase in mutants of the yeast Saccharomyces cerevisiae affected in cAMP metabolism, cAMP-dependent protein phosphorylation and the initiation of glycolysis.Semantic proximity Read ↗

The Cdc25 protein of Saccharomyces cerevisiae is required for normal glucose transport.Semantic proximity Read ↗

Cdc25 is not the signal receiver for glucose induced cAMP response in S. cerevisiae.Semantic proximity Read ↗

A specific mutation in Saccharomyces cerevisiae adenylate cyclase, Cyr1K176M, eliminates glucose- and acidification-induced cAMP signalling and delays glucose-induced loss of stress resistance.Semantic proximity Read ↗

Constitutive glucose-induced activation of the Ras-cAMP pathway and aberrant stationary-phase entry on a glucose-containing medium in the Saccharomyces cerevisiae glucose-repression mutant hex2.Semantic proximity Read ↗

Activation state of the Ras2 protein and glucose-induced signaling in Saccharomyces cerevisiae.Semantic proximity Read ↗

A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose.Semantic proximity Read ↗

New roles for CDC25 in growth control, galactose regulation and cellular differentiation in Saccharomyces cerevisiae.Semantic proximity Read ↗

The high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae is the major determinant of cAMP levels in stationary phase: involvement of different branches of the Ras-cyclic AMP pathway in stress responses.Semantic proximity Read ↗

A mutation in Saccharomyces cerevisiae adenylate cyclase, Cyr1K1876M, specifically affects glucose- and acidification-induced cAMP signalling and not the basal cAMP level.Semantic proximity Read ↗

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