Article
Evidence for ligand-independent transcriptional activation of the human estrogen-related receptor alpha (ERRalpha): crystal structure of ERRalpha ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1alpha.
The Journal of biological chemistry - 19 Nov 2004
Kallen Joerg, Schlaeppi Jean-Marc, Bitsch Francis, Filipuzzi Ireos, Schilb Alain, Riou Virginie, Graham Alexander, Strauss Andre, Geiser Martin, Fournier Brigitte
Abstract excerpt
The crystal structure of the ligand binding domain (LBD) of the estrogen-related receptor alpha (ERRalpha, NR3B1) complexed with a coactivator peptide from peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) reveals a transcriptionally active conformation in the absence of a ligand. This is the first x-ray structure of ERRalpha LBD, solved to a resolution of 2.5 A, and the first structure...
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