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Article

Methotrexate and cytarabine inhibit progression of human lymphoma in NOD/SCID mice carrying a mutant dihydrofolate reductase and cytidine deaminase fusion gene.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Sept 2004

Budak-Alpdogan Tulin, Alpdogan Onder, Banerjee Debabrata, Wang Eunice, Moore Malcolm A S, Bertino Joseph R

Abstract excerpt

An SFG-based retroviral bicistronic vector containing a double-mutant dihydrofolate reductase-cytidine deaminase fusion cDNA (F/S DHFR-CD) with IRES-eGFP confers resistance to both methotrexate (MTX) and cytarabine (ara-C). Two weeks after transplantation with marrow transduced with either a fusion or a control gene (eGFP-IRES-NeoR), human lymphoma (SKI-DLCL-1) cells were injected sc into the flanks of nonobese...

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Source

Identifiers

PMID: 15336657
DOI: 10.1016/j.ymthe.2004.06.115

Genes

DHFR
SKI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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