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[Double-mutant dihydrofolate reductase gene transfection into bone marrow cells protects mice from chemotherapy].

Zhonghua zhong liu za zhi [Chinese journal of oncology] - 1 Aug 2006

Gao Hai-de, Lu Ping, Lu Yang, Pang Kui, Xu Hui-mian, Wang Shu-bao, Chen Jun-qing, Zhao Shi-cheng

Abstract excerpt

OBJECTIVE: To explore the feasibility of transfecting DHFR (human double-mutant dihydrofolate reductase) gene into mouse bone marrow cells and the effect of resistance to high dose MTX chemotherapy. METHODS: After DHFR gene was transfected into mouse bone marrow cells with retroviral vector, the cells were treated with methotrexate (MTX) and then CFU-GM (granulocyte-macrophage colony-forming unit) assay was...

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Source

Identifiers

PMID: 17236551

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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