Article
No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study.
Biological psychiatry - 1 Sept 2004
Kunugi Hiroshi, Iijima Yoshimi, Tatsumi Masahiko, Yoshida Mariko, Hashimoto Ryota, Kato Tadafumi, Sakamoto Kaoru, Fukunaga Takako, Inada Toshiya, Suzuki Tatsuyo, Iwata Nakao, Ozaki Norio, Yamada Kazuo, Yoshikawa Takeo
Abstract excerpt
BACKGROUND: Two previous studies reported a significant association between a missense polymorphism (Val66Met) in the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder; however, contradictory negative results have also been reported, necessitating further investigation. METHODS: We organized a multicenter study of a relatively large sample of 519 patients with bipolar disorder (according to...
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