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Article

An efficient phage plaque screen for the random mutational analysis of the interaction of HIV-1 gp120 with human CD4.

The Journal of biological chemistry - 5 May 1992

Tsui P, Sweet R W, Sathe G, Rosenberg M

Abstract excerpt

A lambda phage expression methodology was adapted to dissect protein/ligand interactions efficiently through the creation and rapid screening of large numbers of mutants. Here we describe the method and its specific application to the interaction between the external envelope glycoprotein of the human immunodeficiency virus (HIV-1), gp120, and the human cell surface protein CD4. Random substitutions were...

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Identifiers

PMID: 1533631

Genes

CDR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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