Article
Computational studies identifying entry inhibitor scaffolds targeting the Phe43 cavity of HIV-1 gp120.
ChemMedChem - 1 Mar 2013
Tintori Cristina, Selvaraj Manikandan, Badia Roger, Clotet Bonaventura, Esté José A, Botta Maurizio
Abstract excerpt
Targeting protein-protein interactions, such as the HIV-1 gp120-CD4 interface, has become a cutting-edge approach in the current drug discovery scenario. Many small molecules have been developed so far as inhibitors of the interaction between CD4 and HIV-1 gp120. However, due to a variety of reasons such as solubility, drug toxicity and drug resistance, these inhibitors have failed to prove clinically useful. As...
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