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Alanine Scanning Mutants of the HIV gp41 Loop

25 May 2005

Abstract excerpt

Based on mutagenesis and structural studies of human immunodeficiency virus (HIV) envelope proteins, the loop region of gp41 is thought to directly interact with gp120. The importance of the HIV gp41 loop region to envelope function has been systematically examined by alanine scanning of all gp41 loop residues and the subsequent characterization of the mutagenic effects on viral entry, envelope expression,...

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PMID: 15917239
DOI: 10.1074/jbc.m414411200

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