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Article

Aberrations of breast cancer susceptibility genes occur early in sporadic breast tumors and in acquisition of breast epithelial immortalization.

Genes, chromosomes & cancer - 1 Nov 2004

Meng Zhen Hang, Ben Yong, Li Zheng, Chew Karen, Ljung Britt-Marie, Lagios Michael D, Dairkee Shanaz H

Abstract excerpt

In the search for early deletion targets in sporadic breast cancer, the analysis of TP53, BRCA1, BRCA2, and ATM revealed loss of heterozygosity (LOH) in tumor cells at 1 or more genes in 18 of 24 cases examined. Notably, in more than 60% of such tumors, LOH was detectable in morphologically normal terminal ductal lobular units (TDLUs) adjacent to carcinoma (LOHint). At BRCA2 and ATM, LOHint was most frequent,...

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Source

Identifiers

PMID: 15334544
DOI: 10.1002/gcc.20089

Genes

ATM
BRCA2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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