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Article

Loss of heterozygosity in benign breast epithelium in relation to breast cancer risk.

Journal of the National Cancer Institute - 5 Jun 2002

Euhus David M, Cler Leslie, Shivapurkar Narayan, Milchgrub Sara, Peters George N, Leitch A Marilyn, Heda Shashank, Gazdar Adi F

Abstract excerpt

The multistage model of breast carcinogenesis suggests that errors in DNA replication and repair generate diversity in the breast epithelium (the mutator phenotype), resulting in selection and expansion of premalignant clones with an acquired survival advantage. We measured loss of heterozygosity (LOH) in breast epithelial cells obtained by random fine-needle aspiration (FNA) biopsy from 30 asymptomatic women...

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Source

Identifiers

PMID: 12048275
DOI: 10.1093/jnci/94.11.858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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