Article
Crucial role of the influenza virus NS2 (NEP) C-terminal domain in M1 binding and nuclear export of vRNP.
FEBS letters - 3 Jan 2011
Shimizu Teppei, Takizawa Naoki, Watanabe Ken, Nagata Kyosuke, Kobayashi Nobuyuki
Abstract excerpt
The influenza virus genome replicates in the host cell nucleus, and the progeny viral ribonucleoproteins (vRNPs) are exported to the cytoplasm prior to maturation. The influenza virus NS2 protein has a nuclear export signal (NES) and binds to M1. It is therefore postulated that vRNP is exported f...
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