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Article

Association analysis of the lymphocyte-specific protein tyrosine kinase (LCK) gene in type 1 diabetes.

Diabetes - 1 Sept 2004

Hulme John S, Barratt Bryan J, Twells Rebecca C J, Cooper Jason D, Lowe Chris E, Howson Joanna M M, Lam Alex C, Smink Luc J, Savage David A, Undlien Dag E, Guja Cristian, Ionescu-Tîirgoviste Constantin, Tuomilehto-Wolf Eva, Tuomilehto Jaakko, Todd John A

Abstract excerpt

Prior data associating the expression of lymphocyte-specific protein tyrosine kinase (LCK) with type 1 diabetes, its critical function in lymphocytes, and the linkage of the region to diabetes in the nonobese diabetic (NOD) mouse model make LCK a premier candidate for a susceptibility gene. Resequencing of LCK in 32 individuals detected seven single nucleotide polymorphisms (SNPs) with allele frequencies >3%,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphocyte Specific Protein Tyrosine Kinase p56(lck)

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 15331563
DOI: 10.2337/diabetes.53.9.2479

Genes

LCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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