Article
Lymphocyte-specific protein tyrosine kinase is a novel risk gene for Alzheimer disease.
Journal of the neurological sciences - 15 Nov 2005
Zhong Wangtao, Yamagata Hidehisa D, Taguchi Keiko, Akatsu Hiroyasu, Kamino Kouzin, Yamamoto Takayuki, Kosaka Kenji, Takeda Masatoshi, Kondo Ikuko, Miki Tetsuro
Abstract excerpt
Lymphocyte-specific protein tyrosine kinase (LCK) is a lymphoid-specific, Src family protein tyrosine kinase that is known to play a pivotal role in T-cell activation and interact with the T-cell coreceptors, CD4 and CD8. It has been shown to be significantly down-regulated in Alzheimer disease (AD) hippocampus compared with non-demented controls. Furthermore, it is located in a previously identified genetic...
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