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Article

Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy.

Molecular and cellular biology - 1 Nov 2007

Zemljic-Harpf Alice E, Miller Joel C, Henderson Scott A, Wright Adam T, Manso Ana Maria, Elsherif Laila, Dalton Nancy D, Thor Andrea K, Perkins Guy A, McCulloch Andrew D, Ross Robert S

Abstract excerpt

Vinculin is a ubiquitously expressed multiliganded protein that links the actin cytoskeleton to the cell membrane. In myocytes, it is localized in protein complexes which anchor the contractile apparatus to the sarcolemma. Its function in the myocardium remains poorly understood. Therefore, we de...

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Identifiers

PMID: 17785437
DOI: 10.1128/MCB.00728-07
PMCID: PMC2169049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17785437-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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