Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin cultures.

The American journal of pathology - 1 Sept 2004

Lippens Saskia, Kockx Mark, Denecker Geertrui, Knaapen Michiel, Verheyen An, Christiaen Ruben, Tschachler Erwin, Vandenabeele Peter, Declercq Wim

Abstract excerpt

Caspase-14 is a nonapoptotic caspase family member whose expression in the epidermis is confined to the suprabasal layers, which consist of differentiating keratinocytes. Proteolytic activation of this caspase is observed in the later stages of epidermal differentiation. In psoriatic skin, a dramatic decrease in caspase-14 expression in the parakeratotic plugs was observed. Topical treatment of psoriatic lesions...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspase Inhibitors
Share to Caspases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholecalciferol

Share to Epidermis

Share to Organ Culture Techniques

Share to Psoriasis

Share to Thymidine

Share to Tretinoin

Source

Open in PubMed Open full text

Identifiers

PMID: 15331408
DOI: 10.1016/S0002-9440(10)63346-9
PMCID: PMC1618612

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin cultures.PMID 15331408Read ↗

Caspase-14-deficient mice are more prone to the development of parakeratosis.Semantic proximity Read ↗

Caspase-14 Is Required for Filaggrin Degradation to Natural Moisturizing Factors in the SkinSemantic proximity Read ↗

Calcipotriol induces apoptosis in psoriatic keratinocytesSemantic proximity Read ↗

Caspase activation in the terminal differentiation of human epidermal keratinocytesSemantic proximity Read ↗

Human papillomavirus 8 E6 disrupts terminal skin differentiation and prevents pro-Caspase-14 cleavageSemantic proximity Read ↗

Delphinidin, a dietary antioxidant, induces human epidermal keratinocyte differentiation but not apoptosis: studies in submerged and three‐dimensional epidermal equivalent modelsSemantic proximity Read ↗

Distribution of caspase‐14 in epidermis and hair follicles is evolutionarily conserved among mammalsSemantic proximity Read ↗

Notch Signaling May Be Involved in the Abnormal Differentiation of Epidermal Keratinocytes in PsoriasisSemantic proximity Read ↗

The differentiation-dependent desmosomal cadherin desmoglein 1 is a novel caspase-3 target that regulates apoptosis in keratinocytes.Semantic proximity Read ↗

Effect of retinoic acid combined with narrow-band ultraviolet B on matrix metalloprotein 13（MMP13）in psoriasisSemantic proximity Read ↗

Aberrant expression of caspase-14 in epithelial tumors.Semantic proximity Read ↗

Induction of normal and psoriatic phenotypes in submerged keratinocyte cultures.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.