Article
The differentiation-dependent desmosomal cadherin desmoglein 1 is a novel caspase-3 target that regulates apoptosis in keratinocytes.
The Journal of biological chemistry - 10 Feb 2006
Dusek Rachel L, Getsios Spiro, Chen Feng, Park Jung K, Amargo Evangeline V, Cryns Vincent L, Green Kathleen J
Abstract excerpt
Although a number of cell adhesion proteins have been identified as caspase substrates, the potential role of differentiation-specific desmosomal cadherins during apoptosis has not been examined. Here, we demonstrate that UV-induced caspase cleavage of the human desmoglein 1 cytoplasmic tail results in distinct 17- and 140- kDa products, whereas metalloproteinase-dependent shedding of the extracellular adhesion...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.