Article
Induction of normal and psoriatic phenotypes in submerged keratinocyte cultures.
Journal of cellular physiology - 1 Aug 1996
Van Ruissen F, de Jongh G J, Zeeuwen P L, Van Erp P E, Madsen P, Schalkwijk J
Abstract excerpt
Lesional psoriatic epidermis displays a number of phenotypic changes that are distinct from the differentiation program found in normal interfollicular epidermis. In psoriatic epidermis, keratinocytes are hyperproliferative and several differentiation-associated molecules are expressed that are absent in normal skin (e.g., cytokeratins (CK) 6, 16, and 17, and the epidermal proteinase inhibitor SKALP/ elafin). In...
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