Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Caspase-14-deficient mice are more prone to the development of parakeratosis.

The Journal of investigative dermatology - 1 Mar 2013

Hoste Esther, Denecker Geertrui, Gilbert Barbara, Van Nieuwerburgh Filip, van der Fits Leslie, Asselbergh Bob, De Rycke Riet, Hachem Jean-Pierre, Deforce Dieter, Prens Errol P, Vandenabeele Peter, Declercq Wim

Abstract excerpt

Caspase-14 is an important protease in the proper formation of a fully functional skin barrier. Newborn mice that are deficient in caspase-14 exhibit increased transepidermal water loss and are highly sensitive to UVB-induced photodamage. Decreased caspase-14 expression and incomplete caspase-14 processing in lesional psoriatic parakeratotic stratum corneum has been reported previously. In this study, we show...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aminoquinolines
Share to Caspases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Differentiation

Share to Cell Proliferation

Share to Disease Models, Animal

Share to Keratinocytes

Share to Mice, Knockout

Share to Psoriasis

Source

Identifiers

PMID: 23014340
DOI: 10.1038/jid.2012.350

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Caspase-14-deficient mice are more prone to the development of parakeratosis.PMID 23014340Read ↗

Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin cultures.Semantic proximity Read ↗

Caspase-14 Is Required for Filaggrin Degradation to Natural Moisturizing Factors in the SkinSemantic proximity Read ↗

Distribution of caspase‐14 in epidermis and hair follicles is evolutionarily conserved among mammalsSemantic proximity Read ↗

CARD14-Mediated Activation of Paracaspase MALT1 in Keratinocytes: Implications for Psoriasis.Semantic proximity Read ↗

Caspase-14 protects against epidermal UVB photodamage and water lossSemantic proximity Read ↗

Development of atopic dermatitis-like skin disease from the chronic loss of epidermal caspase-8Semantic proximity Read ↗

Loss-of-function mutations in caspase recruitment domain-containing protein 14 (CARD14) are associated with a severe variant of atopic dermatitisSemantic proximity Read ↗

Intrinsic Abnormalities of Keratinocytes Initiate Skin Inflammation through the IL-23/T17 Axis in a MALT1-Dependent MannerSemantic proximity Read ↗

Aberrant expression of caspase-14 in epithelial tumors.Semantic proximity Read ↗

Impaired skin regeneration and remodeling after cutaneous injury and chemically induced hyperplasia in taps-transgenic mice.Semantic proximity Read ↗

The paracaspase MALT1 mediates CARD14-induced signaling in keratinocytes.Semantic proximity Read ↗

RIP4 is an ankyrin repeat-containing kinase essential for keratinocyte differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.