Article
MPO and SOD2 polymorphisms, gender, and the risk of non-small cell lung carcinoma.
Cancer letters - 8 Oct 2004
Liu Geoffrey, Zhou Wei, Wang Lisa I, Park Sohee, Miller David P, Xu Li Lian, Wain John C, Lynch Thomas J, Su Li, Christiani David C
Abstract excerpt
Manganese superoxide dismutase (SOD2) and myeloperoxidase (MPO) are polymorphic enzymes involved in reactive oxidative species metabolism. In this case-control study (830 non-small cell lung carcinoma (NSCLC) patients; 1119 controls) we evaluated whether the MPO -G463A polymorphism (associated with a novel estrogen receptor binding site) modifies the association between the SOD2 Ala16Val polymorphism and NSCLC...
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