Article
MASH1 activates expression of the paired homeodomain transcription factor Phox2a, and couples pan-neuronal and subtype-specific components of autonomic neuronal identity.
Development (Cambridge, England) - 1 Feb 1998
Lo L, Tiveron M C, Anderson D J
Abstract excerpt
We have investigated the genetic circuitry underlying the determination of neuronal identity, using mammalian peripheral autonomic neurons as a model system. Previously, we showed that treatment of neural crest stem cells (NCSCs) with bone morphogenetic protein-2 (BMP-2) leads to an induction of...
Topics
- Animals
- Autonomic Pathways
- Basic Helix-Loop-Helix Transcription Factors
- Bone Morphogenetic Protein 2
- Bone Morphogenetic Proteins
- Cell Differentiation
- Cells, Cultured
- DNA-Binding Proteins
- Drosophila Proteins
- Female
- Glial Cell Line-Derived Neurotrophic Factor Receptors
- Homeodomain Proteins
- In Situ Hybridization
- Male
- Mice
- Mice, Knockout
- Mutation
- Nerve Tissue Proteins