Article
Functional deficiency in IL-7 caused by an N-ethyl-N-nitrosourea-induced point mutation.
Genetics - 1 Feb 2007
Feng Jianxun, Wang Hongsheng, Morse Herbert C
Abstract excerpt
N-ethyl-N-nitrosourea (ENU)-induced mutagenesis provides a powerful approach for identifying genes involved in immune regulation and diseases. Here we describe a new mutant strain, HLB368, with hereditary leukopenia. At necropsy, the mutant mice had very small thymuses and spleens. All but the inguinal nodes were absent and there were no Peyer's patches. By flow cytometry, the ratios of T-cell subsets were...
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