Article
A natural hypomorphic variant of the apoptosis regulator Gimap4/IAN1.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2007
Carter Christine, Dion Carine, Schnell Silke, Coadwell W John, Graham Margaret, Hepburn Lucy, Morgan Geoffrey, Hutchings Amanda, Pascall John C, Jacobs Heinz, Miller J Ross, Butcher Geoffrey W
Abstract excerpt
The Gimap/IAN family of GTPases has been implicated in the regulation of cell survival, particularly in lymphomyeloid cells. Prosurvival and prodeath properties have been described for different family members. We generated novel serological reagents to study the expression in rats of the prodeath family member Gimap4 (IAN1), which is sharply up-regulated at or soon after the stage of T cell-positive selection in...
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