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Article

Disruption of the Candida albicans CYB5 gene results in increased azole sensitivity.

Antimicrobial agents and chemotherapy - 1 Sept 2004

Rogers K M, Pierson C A, Culbertson N T, Mo C, Sturm A M, Eckstein J, Barbuch R, Lees N D, Bard M

Abstract excerpt

Sterol synthesis in fungi is an aerobic process requiring molecular oxygen and, for several cytochrome-mediated reactions, aerobically synthesized heme. Cytochrome b(5) is required for sterol C5-6 desaturation and the encoding gene, CYB5, is nonessential in Saccharomyces cerevisiae. Cyb5p and Ncp1p (cytochrome P-450 reductase) appear to have overlapping functions in this organism, with disruptions of each alone...

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Identifiers

PMID: 15328107
DOI: 10.1128/AAC.48.9.3425-3435.2004
PMCID: PMC514794

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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