Article
STB5 is a negative regulator of azole resistance in Candida glabrata.
Antimicrobial agents and chemotherapy - 1 Feb 2013
Noble Jason A, Tsai Huei-Fung, Suffis Sara D, Su Qin, Myers Timothy G, Bennett John E
Abstract excerpt
The opportunistic yeast pathogen Candida glabrata is recognized for its ability to acquire resistance during prolonged treatment with azole antifungals (J. E. Bennett, K. Izumikawa, and K. A. Marr. Antimicrob. Agents Chemother. 48:1773-1777, 2004). Resistance to azoles is largely mediated by the transcription factor PDR1, resulting in the upregulation of ATP-binding cassette (ABC) transporter proteins and drug...
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