Cloning and characterization of a yeast cytochrome b5-encoding gene which suppresses ketoconazole hypersensitivity in a NADPH-P-450 reductase-deficient strain.

doi:10.1016/0378-1119(94)90366-2

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Article

Cloning and characterization of a yeast cytochrome b5-encoding gene which suppresses ketoconazole hypersensitivity in a NADPH-P-450 reductase-deficient strain.

Gene - 3 May 1994

Truan G, Epinat J C, Rougeulle C, Cullin C, Pompon D

Abstract excerpt

Cytochrome P-450 (Cyp) 51 or lanosterol-C14-demethylase is the main target for antifungal compounds of the triazole family like ketoconazole (Kz). Disruption of the associated NADPH-P-450 reductase-encoding gene (YRED) is not lethal, but decreases by about 20-fold the Kz resistance (KzR) of wild-...

Topics

Amino Acid Sequence
Base Sequence
Cloning, Molecular
Cytochromes b5
DNA, Fungal
Drug Resistance, Microbial
Ketoconazole
Molecular Sequence Data
NADPH-Ferrihemoprotein Reductase
Open Reading Frames
Phenotype
Restriction Mapping
Saccharomyces cerevisiae
Sequence Homology, Amino Acid
Transformation, Genetic

Source

Open in PubMed

Identifiers

PMID: 8181746
DOI: 10.1016/0378-1119(94)90366-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8181746-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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