Article
Gene silencing with RNA interference in the human pathogenic fungus Aspergillus fumigatus.
FEMS microbiology letters - 15 Aug 2004
Mouyna Isabelle, Henry Christine, Doering Tamara L, Latgé Jean-Paul
Abstract excerpt
Aspergillus fumigatus is an opportunistic pathogenic fungus which causes fatal invasive aspergillosis among immunocompromised patients. To obtain a better understanding of the key elements involved in A. fumigatus virulence and to identify possible drug targets, it is necessary to be able to generate gene-deletion strains. Unfortunately, the molecular techniques available do not include a rapid method to disrupt...
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