Article
An antisense-based functional genomics approach for identification of genes critical for growth of Candida albicans.
Nature biotechnology - 1 Mar 2001
De Backer M D, Nelissen B, Logghe M, Viaene J, Loonen I, Vandoninck S, de Hoogt R, Dewaele S, Simons F A, Verhasselt P, Vanhoof G, Contreras R, Luyten W H
Abstract excerpt
Converting the complete genome sequence of Candida albicans into meaningful biological information will require comprehensive screens for identifying functional classes of genes. Most systems described so far are not applicable to C. albicans because of its difficulty with mating, its diploid nature, and the lack of functional random insertional mutagenesis methods. We examined artificial gene suppression as a...
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