Article
Structure of human isovaleryl-CoA dehydrogenase at 2.6 A resolution: structural basis for substrate specificity,.
Biochemistry - 15 Jul 1997
Tiffany K A, Roberts D L, Wang M, Paschke R, Mohsen A W, Vockley J, Kim J J
Abstract excerpt
Isovaleryl-CoA dehydrogenase (IVD) belongs to an important flavoprotein family of acyl-CoA dehydrogenases that catalyze the alpha,beta-dehydrogenation of their various thioester substrates. Although enzymes from this family share similar sequences, catalytic mechanisms, and structural properties,...
Topics
- Acyl Coenzyme A
- Acyl-CoA Dehydrogenase
- Acyl-CoA Dehydrogenase, Long-Chain
- Binding Sites
- Coenzyme A
- Crystallography, X-Ray
- Humans
- Isovaleryl-CoA Dehydrogenase
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Oxidoreductases
- Oxidoreductases Acting on CH-CH Group Donors
- Protein Binding
- Protein Conformation
- Protein Folding
- Protein Structure, Secondary
- Protein Structure, Tertiary