Article
Gene expression alterations of human peripheral blood monocytes induced by medium-term treatment with the TH2-cytokines interleukin-4 and -13.
Cytokine - 21 Jun 2005
Chaitidis Pavlos, O'Donnell Valerie, Kuban Ralf J, Bermudez-Fajardo Alexandra, Ungethuem Ute, Kühn Hartmut
Abstract excerpt
The TH2-cytokines interleukins-4 and -13 severely alter gene expression of monocytic cells. We quantified the impact of interleukins-4 and -13 on the gene expression pattern of human peripheral blood monocytes applying a strategy that involved microarray hybridization, RT-PCR, immunohistochemistry and activity assays. After 3 days of continuous cytokine exposure the six most strongly upregulated gene products...
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