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Article

Characterization and cell cycle regulation of the related human telomeric proteins Pin2 and TRF1 suggest a role in mitosis

9 Dec 1997

Abstract excerpt

Telomeres are essential for preserving chromosome integrity during the cell cycle and have been specifically implicated in mitotic progression, but little is known about the signaling molecule(s) involved. The human telomeric repeat binding factor protein (TRF1) is shown to be important in regulating telomere length. However, nothing is known about its function and regulation during the cell cycle. The sequence...

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Share to DNA Repair Mechanisms
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Identifiers

PMID: 9391075
DOI: 10.1073/pnas.94.25.13618

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Related research

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Characterization and cell cycle regulation of the related human telomeric proteins Pin2 and TRF1 suggest a role in mitosisPMID 9391075Read ↗

TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.Semantic proximity Read ↗

Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenanceSemantic proximity Read ↗

Telomeric Protein Pin2/TRF1 as an Important ATM Target in Response to Double Strand DNA BreaksSemantic proximity Read ↗

Telomerase Inhibitor PinX1 Provides a Link between TRF1 and Telomerase to Prevent Telomere ElongationSemantic proximity Read ↗

A critical role for Pin2/TRF1 in ATM-dependent regulation. Inhibition of Pin2/TRF1 function complements telomere shortening, radiosensitivity, and the G(2)/M checkpoint defect of ataxia-telangiectasia cells.Semantic proximity Read ↗

Telomere Maintenance through Spatial Control of Telomeric ProteinsSemantic proximity Read ↗

The Protein Network Surrounding the Human Telomere Repeat Binding Factors TRF1, TRF2, and POT1Semantic proximity Read ↗

PinX1, a Telomere Repeat-binding Factor 1 (TRF1)-interacting Protein, Maintains Telomere Integrity by Modulating TRF1 Homeostasis, the Process in Which Human Telomerase Reverse Transcriptase (hTERT) Plays Dual RolesSemantic proximity Read ↗

TIN2 Mediates Functions of TRF2 at Human TelomeresSemantic proximity Read ↗

Cyclin B-dependent kinase 1 regulates human TRF1 to modulate the resolution of sister telomeresSemantic proximity Read ↗

Genome-wide YFP Fluorescence Complementation Screen Identifies New Regulators for Telomere Signaling in Human CellsSemantic proximity Read ↗

Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes.Semantic proximity Read ↗

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