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Article

Congenital Hyperinsulinism and Hypopituitarism Attributable to a Mutation in FOXA2.

The Journal of clinical endocrinology and metabolism - 1 Mar 2018

Vajravelu Mary Ellen, Chai Jinghua, Krock Bryan, Baker Samuel, Langdon David, Alter Craig, De León Diva D

Abstract excerpt

Context: Persistent hypoglycemia in the newborn period most commonly occurs as a result of hyperinsulinism. The phenotype of hypoketotic hypoglycemia can also result from pituitary hormone deficiencies, including growth hormone and adrenocorticotropic hormone deficiency. Forkhead box A2 (Foxa2) is a transcription factor shown in mouse models to influence insulin secretion by pancreatic β cells. In addition, Foxa2...

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Share to Congenital Hyperinsulinism
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29329447
DOI: 10.1210/jc.2017-02157
PMCID: PMC6276717

Genes

FOXA2
ABCC8
GLI2
HADH
SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

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Congenital Hyperinsulinism and Hypopituitarism Attributable to a Mutation in FOXA2.PMID 29329447Read ↗

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