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Article

Genetic Pathogenesis and Treatment of Forkhead Box A2 Hyperinsulinemia.

Endocrine, metabolic & immune disorders drug targets - 1 Jan 2026

Ji Yangmingyue, Chen Congli, Sang Yanmei

Abstract excerpt

Congenital hyperinsulinemia (CHI) is a clinically heterogeneous disorder that is the leading cause of persistent and recurrent hypoglycemia in infancy and childhood. There are 39 pathogenic genes associated with CHI. The forkhead box A2 (FOXA2) gene variants that induce forkhead box A2 hyperinsulinemia (FOXA2-HI) are extremely rare. This review describes the genetic pathogenesis and treatment progress of FOXA2-HI...

Read the complete abstract on PubMed

Topics

Humans
Congenital Hyperinsulinism
Genetic Predisposition to Disease
Animals
Forkhead Transcription Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 41140207
DOI: 10.2174/0118715303396043250929055236

Genes

FOXA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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