Article
A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development.
PLoS biology - 1 Aug 2004
Zarbalis Konstantinos, May Scott R, Shen Yiguo, Ekker Marc, Rubenstein John L R, Peterson Andrew S
Abstract excerpt
Although the mechanisms that regulate development of the cerebral cortex have begun to emerge, in large part through the analysis of mutant mice (Boncinelli et al. 2000; Molnar and Hannan 2000; Walsh and Goffinet 2000), many questions remain unanswered. To provide resources for further dissecting cortical development, we have carried out a focused screen for recessive mutations that disrupt cortical development....
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