Article
A forward genetic screen with a thalamocortical axon reporter mouse yields novel neurodevelopment mutants and a distinct emx2 mutant phenotype.
Neural development - 7 Jan 2011
Dwyer Noelle D, Manning Danielle K, Moran Jennifer L, Mudbhary Raksha, Fleming Michael S, Favero Carlita B, Vock Vita M, O'Leary Dennis D M, Walsh Christopher A, Beier David R
Abstract excerpt
BACKGROUND: The dorsal thalamus acts as a gateway and modulator for information going to and from the cerebral cortex. This activity requires the formation of reciprocal topographic axon connections between thalamus and cortex. The axons grow along a complex multistep pathway, making sharp turns, crossing expression boundaries, and encountering intermediate targets. However, the cellular and molecular components...
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