Article
(2E,6Z,10E)-7-hydroxymethyl-3,11,15-trimethyl-2,6,10,14-hexadecatetraen-1-ol (Plaunotol) increases cyclooxygenase-2 expression via nuclear factor kappaB and cyclic AMP response element in rat gastric epithelial cells.
European journal of pharmacology - 7 Nov 2005
Fu Hai ying, Yabe Yuki, Asahi Kayoko, Hayashi Yujiro, Murata Hiroaki, Eguchi Hiroshi, Tsujii Masahiko, Tsuji Shingo, Kawano Sunao
Abstract excerpt
Plaunotol, [(2E,6Z,10E)-7-hydroxymethyl-3,11,15-trimethyl-2,6,10,14-hexadecatetraen-1-ol], a gastroprotective agent, increases the prostaglandin production in the gastric mucosa and accelerates ulcer healing. The precise mechanisms underlying the gastroprotective actions by plaunotol are not known. On the other hand, cyclooxygenase (COX)-2 is a key enzyme in PGE(2) production and its induction is thought to have...
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