Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis.

Arthritis research & therapy - 1 Jan 2004

Kojima Fumiaki, Naraba Hiroaki, Miyamoto Satoshi, Beppu Moroe, Aoki Haruhito, Kawai Shinichi

Abstract excerpt

Prostaglandin E synthase (PGES) including isoenzymes of membrane-associated PGES (mPGES)-1, mPGES-2, and cytosolic PGES (cPGES) is the recently identified terminal enzyme of the arachidonic acid cascade. PGES converts prostaglandin (PG)H2 to PGE2 downstream of cyclooxygenase (COX). We investigated the expression of PGES isoenzyme in articular chondrocytes from patients with osteoarthritis (OA). Chondrocytes were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cartilage, Articular
Share to Chondrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclooxygenase 2

Share to Indoles

Share to Interleukin-1

Share to Intramolecular Oxidoreductases

Share to Osteoarthritis

Share to Prostaglandin-Endoperoxide Synthases

Source

Open in PubMed Open full text

Identifiers

PMID: 15225371
DOI: 10.1186/ar1195
PMCID: PMC464891

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis.PMID 15225371Read ↗

mPGES-1 as a novel target for arthritisSemantic proximity Read ↗

Differentiation status-dependent regulation of cyclooxygenase-2 expression and prostaglandin E2 production by epidermal growth factor via mitogen-activated protein kinase in articular chondrocytes.Semantic proximity Read ↗

Prolonged Application of High Fluid Shear to Chondrocytes Recapitulates Gene Expression Profiles Associated with OsteoarthritisSemantic proximity Read ↗

Nuclear Factor-Kappa B Regulates Inducible Prostaglandin E Synthase Expression in Human Amnion Mesenchymal Cells1Semantic proximity Read ↗

Inhibition of cyclooxygenase-2 expression and prostaglandin E2 production in chondrocytes by avocado soybean unsaponifiables and epigallocatechin gallate.Semantic proximity Read ↗

Induction of an inflammatory and prodegradative phenotype in autologous fibroblast-like synoviocytes by the infrapatellar fat pad from patients with knee osteoarthritis.Semantic proximity Read ↗

Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritisSemantic proximity Read ↗

PGE2 induces IL-6 in orbital fibroblasts through EP2 receptors and increased gene promoter activity: implications to thyroid-associated ophthalmopathy.Semantic proximity Read ↗

Potential Role of Microsomal Prostaglandin E Synthase-1 in TumorigenesisSemantic proximity Read ↗

Human chondrocyte culture models for studying cyclooxygenase expression and prostaglandin regulation of collagen gene expressionSemantic proximity Read ↗

Jak2 dampens the induction by IL-1beta of prostaglandin endoperoxide H synthase 2 expression in human orbital fibroblasts: evidence for divergent influence on the prostaglandin E2 biosynthetic pathway.Semantic proximity Read ↗

Prostaglandin E2 is a novel inducer of oncostatin-M expression in macrophages and microglia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.