Article
The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing spondylitis.
American journal of human genetics - 1 Oct 2004
Timms Andrew E, Crane Alison M, Sims Anne-Marie, Cordell Heather J, Bradbury Linda A, Abbott Aaron, Coyne Mark R E, Beynon Owen, Herzberg Ibi, Duff Gordon W, Calin Andrei, Cardon Lon R, Wordsworth B Paul, Brown Matthew A
Abstract excerpt
Ankylosing spondylitis (AS) is a common and highly heritable inflammatory arthropathy. Although the gene HLA-B27 is almost essential for the inheritance of the condition, it alone is not sufficient to explain the pattern of familial recurrence of the disease. We have previously demonstrated suggestive linkage of AS to chromosome 2q13, a region containing the interleukin 1 (IL-1) family gene cluster, which...
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