Article
No allelic variation in genes with high gliadin homology in patients with celiac disease and type 1 diabetes.
Immunogenetics - 1 Aug 2004
Nielsen Christian, Hansen Dorte, Husby Steffen, Jacobsen Bendt Brock, Lillevang Søren T
Abstract excerpt
Celiac disease (CD) is a complex inflammatory disorder of the small intestine, induced by dietary gluten in genetically susceptible individuals. CD is strongly associated with HLA-DQ2 and it has recently been established that gut-derived DQ2-restricted T cells from patients with CD predominantly recognize gluten-derived peptides in which specific glutamine residues are deamidated to glutamic acid by tissue...
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