Article
Human leukocyte antigen-DQ2 homozygosity and the development of refractory celiac disease and enteropathy-associated T-cell lymphoma.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Mar 2006
Al-Toma Abdulbaqi, Goerres Marije S, Meijer Jos W R, Peña A Salvador, Crusius J Bart A, Mulder Chris J J
Abstract excerpt
BACKGROUND & AIMS: Celiac disease (CD) is a common gluten-sensitive enteropathy associated with human leukocyte antigen (HLA)-DQ2 and HLA-DQ8. The aim of this study was to determine if a particular HLA-DQ subtype predisposes to complications such as refractory CD with (RCD II) or without aberrant T cells (RCD I), and enteropathy-associated T-cell lymphomas (EATL). METHODS: Molecular HLA-DQ typing was performed on...
Topics
- Adult
- Aged
- Aged, 80 and over
- Antigens, CD
- Case-Control Studies
- Celiac Disease
- Female
- Genetic Predisposition to Disease
- HLA-DQ Antigens
- Homozygote
- Humans
- Lymphoma, T-Cell
- Male
- Middle Aged
