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Article

Detection of YMDD motif mutants by oligonucleotide chips in lamivudine-untreated patients with chronic hepatitis B virus infection.

Journal of Korean medical science - 1 Aug 2004

Heo Jeong, Cho Mong, Kim Hyung Hoi, Shin Young Min, Jang Hyun Jung, Park Hee Kyung, Kim Cheol Min, Kim Gwang Ha, Kang Dae Hwan, Song Geun Am, Yang Ung Suk

Abstract excerpt

Lamivudine, a nucleoside analogue, has been used widely as an effective antiviral agent for the treatment of patients with chronic hepatitis B virus (HBV) infection. However, the YMDD motif mutation of HBV polymerase resistant to lamivudine occurs very frequently after long term therapy. We developed an oligonucleotide chip for the detection of YMDD motif mutants resistant to lamivudine and investigated the...

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Identifiers

PMID: 15308845
DOI: 10.3346/jkms.2004.19.4.541
PMCID: PMC2816888

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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